Experiment 1116808

Details

PropertyValue
Pharmacology
OrganismEmpty organism
CitationNOVOKHATSKII,AS: AUELBEKOV,SA: KABIROV,SK: ASLANOV,KA:. (1981). ANTIVIRAL AND INTERFERON-INDUCING ACTIVITY OF GOSSYPOL AND SODIUM GOSSYPOL-BETA-AMINOETHYLSULFONATE IN CELL CULTURES.. ()
Amount utilized
Compound isolated
DiseaseGOSSYPOL(II) AND GOSSYPOL-BETA-AMINOETHYLSULFONATE(I) WERE TESTED FOR INTERFERON-INDUCING EFFECTS IN SINDBIS VIRUS-INFECTED CHICK EMBRYO FIBROBLASTS. I WAS MORE ACTIVE THAN II AND WAS ALSO LESS TOXIC TO THE CELLS. THE TWO COMPOUNDS SHOUWED DIFFERENT PATTERNS OF INTERFERON-INDUCING ACTIVITY IN FIBROBLAST CELLS. MAXIMUM ACTIVITY FOR II WAS AT THE CYTOTOXIC LEVEL OF 125 MCG/ML. WITH I, TWO PEAKS OF ACTIVITY WERE SEEN: AT THE NONTOXIC ANTIVIRAL DOSE OF 62 MCG/ML AND AT THE SUBTOXIC DOSE OF 250 MCG/ML.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalCELL CULTURE
Dose expressionCONC USED