Experiment 1117049
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IM |
| Organism | Empty organism |
| Citation | WANG,DW: LIU,XT:. (1983). EFFECT OF QINGHAOSU (ARTEMISININE) SUSPENSION IN OIL ON ULTRASTRUCTURE OF MYOCARDIUM IN RHESUS MONKEYS.. 4(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | DOSING DAILY FOR 14 DAYS TO 30 ANIMALS GAVE SEVERE ULTRASTRUCTURAL DAMAGES OF MYOCARDIUM IN ANIMALS KILLED ON DAY 3 AFTER THE LAST INJECTION. CHANGES INVOLVED OBVIOUS REDUCTION OF GLYCOGEN GRANULES, SWELLING AND VACUOLAR DEGENERATION OF SOME MITOCHONDRIA, COACERVATION AND HOMOGENIZATION OF CRISTAE, DILATION OF ENDOPLASMIC RETICULUM, DERANGEMENT, FUSION AND HOMOGENIZATION OF FILAMENTS. IN SOME CASES THERE WAS EVEN DISSOLUTION AND NECROSIS AND EXTENSION OF SPACE OF INTERCALATED DISKS. |
| Dose amount | 96.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | MONKEY(RHESUS) |
| Per unit | KG |
| Dose expression | DOSE |