Experiment 1117286
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | COUTINHO,EM:. (1982). CLINICAL TRIALS WITH GOSSYPOL.. 9(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECT OF GOSSYPOL ON FERTILITY WAS INVESTIGATED IN EIGHT MEN FOR PERIODS OF 6-12 MONTHS. DOSING WAS DAILY FOR 4 MONTHS FOLLOWED BY 20 MG ON ALTERNATE DAYS. REDUCTION IN SPERM NUMBER OCCURRED AFTER 45 DAYS AND AZOOSPERMIA AT THE END OF 4 MONTHS OF TREATMENT. NO CHANGE IN SEMEN VOLUME WAS DETECTED. THE RESPONES TO LHRH AND HCG WAS NORMAL DURING THE TREATMENT. TESTOSTERONE LEVELS REMAINED WITHIN THE NORMAL RANGE. NONE OF THE SUBJECTS REPORTED LOSS OF LIBIDO OR POTENCY. BLOOD CHEMISTRY WAS NORMAL. THERE WAS NO SIGNIFICANT CHANGES IN BLOOD PRESSURE OR BODY WEIGHT. REVERSIBILITY WAS FASTER IN MEN WHO TOOK THE DRUG FOR SHORT PERIODS OF TIME. THE STUDY WAS CARRIED OUT IN BRAZIL. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Gender | MALE |