Experiment 1117938
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | ROVAN,E: WEINBAUER,GF: FRICK,J: ADAM,H:. (1983). ULTRASTRUCTURAL ANALYSIS OF RAT TESTES AFTER GOSSYPOL ACETIC ACID (GAA) TREATMENT.. 11(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS INVESTIGATION WAS CARRIED OUT TO SHOW THE HISTOLOGICAL AND ULTRASTRUCTURAL ALTERATIONS IN RAT TESTES 10 WEEKS AFTER GOSSYPOL ACETIC ACID TREATMENT (DAILY DOSING). THE MORPHOLOGICAL FINDINGS IN THE INTERSTITIAL COMPARTMENT WERE COMPARED WITH THE DATA FROM STUDIES CARRIED OUT TO INVESTIGATE THE TESTOSTERONE BIOSYNTHESIS IN GOSSYPOL ACETIC ACID TREATED RATS. NO MORPHOLOGICAL CHANGES IN THE EPIDIDYMAL AND VASAL EPITHELIA WERE FOUND: HOWEVER, THE GERMINAL EPITHELIAL CELLS SHOWED VACUOLIZATION,PYCNOSIS,DISCONNECTIONS OF JUNCTIONS,CYTOLYSIS AND EXFOLIATION OF GERM CELLS FROM THE EPITHELIUM. THE SERTOLI CELLS WERE AFFECTED ALSO. THE TITLE COMPOUND SEEMED TO STIMULATE THE PHYSIOLOGICAL ACTIVITY PATHOLIGICALLY: CELLULAR ORGANELLES SUCH AS MITOCHONDRIA, ENDOPLASMIC RETICULUM, LYSOSOMAL VACUOLES, PIGMENT GRANULES AND NUCLEI WERE ENLARGED IN SIZE AND NUMBER OR MALFORMED IN SHAPE. THE CELLULAR CONTACT WAS OFTEN RESTRICTED TO SPOTS OR COMPLETELY DISCONNECTED. IF THE TITLE COMPOUND WAS ADMINISTERED FOR A LONGER PERIOD OF TIME SOME SERTOLI CELLS WERE FOUND TO BE UNABLE TO WITHSTAND THE TOXIC STIMULUS,AND THE CELL BECOME NECROTIC. IN CONTRAST TO THE TOXIC PROCESS IN THE GERMINAL AND SERTOLI CELLS THE LEYDIG CELL COMPARTMENT DID NOT SHOW ANY CHANGES IN FINE STRUCTURE AND THEREFORE TESTOSTERONE BIOSYNTHESIS WAS PRESUMED TO BE INTACT. |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |