| Disease | 12 BRAZILIAN MEN WERE TREATED WITH THE TITLE COMPOUND FOR ONE YEAR. DAILY DOSING FOR 4 MONTHS,FOLLOWED BY A MAINTENANCE DOSE OF 20 MG EVERY OTHER DAY. 10 MEN BECAME AZOOSPERMIC AT THE END OF THE FOURTH MONTH.
2 OTHER MEN DEVELOPED MARKED OLIGOSPERMIA WITH NECROSPERMIA.EXCEPT FOR ONE MAN WHO COMPLAINED OF TRANSIENT LISTLESSNESS AND FATIGUE,THE SUBJECTS REPORTED NO SIDE EFFECTS DURING TREATMENT.
NO CHANGES IN LIBIDO OR POTENCY WERE REPORTED AND PLASMA TESTOSTERONE REMAINED UNCHANGED. BLOOD CHEMISTRY VALUES(RBC,WBC,CHOLESTEROL,GLUCOSE,TRIGLYCERIDES,ACID PHOSPHATASE,UREA,TRANSAMINASES,SODIUM AND POTASSIUM)WERE NOT CHANGED.SIGNIFICANTLY.
THE RESPONSE OF THE PITUITARY TO GONADOTROPIN-RELEASING HORMONE STIMULATION AND THE RESPONSE OF THE TESTIS TO GONADOTROPIN STIMULATION APPEARED NORMAL.
AFTER TREATMENT,THE SPERM COUNTS REVERTED TO ESSENTIALLY NORMAL LEVELS IN 8 OF 12 MEN. IN 4 MEN,AZOOSPERMIA CONTINUED ONE YEAR AFTER DISCONTINUATION OF GOSSYPOL TREATMENT.
RETROGRADE PHLEBOGRAPHY CARRIED OUT IN 3 OF THE 4 MEN WHO REMAINED AZOOSPERMIC AFTER DISCONTINUATION OF THERAPY REVEALED SUBCLINICAL VARICOCELE. |