Experiment 1132208
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | ZHOU,JY: ZHANG,Y: ZHANG,SX: BO,AH: HAN,SQ: CHEN,NZ:. (1981). A HISTOLOGICAL STUDY OF THE EFFECT OF GOSSYPOL ON THE ANTERIOR LOBE OF PITUITARY OF CASTRATED HOGS.. 12() |
| Amount utilized | |
| Compound isolated | |
| Disease | NINE CASTRATED HOGS WERE DIVIDED INTO TWO GROUPS.THE EXPERIMENTAL GROUP CONSISTED OF 7 ANIMALS AND WERE DOSED WITH 20 MG/KG/DAY FOR 15 DAYS AND 50 MG/KG/DAY FOR ANOTHER 15 DAYS.TWO ANIMALS IN THIS GROUP WERE SACRIFICED ON THE 15TH AND 28TH DAYS. GOSSYPOL WAS DISCONTINUED ON THE 30TH DAY IN THE REMAINING 5 HOGS AND THEY WERE KILLED ON THE 2ND,7TH,13TH AND 18TH DAY THEREAFTER. THE PITUITARY GLANDS WERE REMOVED AND PROCESSED.MORPHOLOGICAL CHANGES OF VARIOUS DEGREES WERE OBSERVED IN ALL CELL TYPES OF THE PITUITARY AFTER GOSSYPOL DOSING. CHANGES OF LH AND FSH CELLS,E.G. ENLARGEMENT OF GOLGI AREA AND INCREASE IN CELL NUMBER. ETC. MAY NOT BE DUE TO THE DIRECT EFFECT OF GOSSYPOL. BETA CELL SHOWED VACUOLIZATION AND HEMORRHAGE AND OCCURRED DIFFUSELY ON THE WHOLE BODY AFTER DOSING WITH GOSSYPOL FOR ONE MONTH. BETA CELL SHOWED VACUOLIZATION AND HEMORRHAGE AND OCCURRED DIFFUSELY ON THE WHOLE BODY AFTER DOSING WITH GOSSYPOL FOR ONE MONTH. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | PIG |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |