Experiment 1134439
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | SOUFIR,JC: DANTEC,MC: JEGOU,B: FOLLIOT,R: GARNIER,DH: ANDRE,J: STELLY,N:. (1984). EPIDIDYMAL EFFECTS OF GOSSYPOL.. 1984(II) |
| Amount utilized | |
| Compound isolated | |
| Disease | DAILY DOSING,SIX DAYS PER WEEK,FOR FIVE WEEKS PRODUCED NO CHANGE IN TESTIS WEIGHT,TESTIS MORPHOLOGY(INCLUDING GERM CELLS)SERTOLI CELL FUNCTION(NOTABLY TESTICULAR FLUID PRODUCTION)OR LEYDIG CELL FUNCTION. (SERUM TESTOSTERONE,IN VITRO TESTOSTERONE PRODUCTION).THERE WERE STRIKING ALTERATIONS OF EPIDIDYMAL FUNCTION,INCLUDING REDUCED EPIDIDYMAL WEIGHTS,DECREASES IN BIOCHEMICAL INDICES OF EPIDIDYMAL SECRETION(CARNITINE,INOSITOL),MAJOR ULTRASTRUCTURALCHANGES. IN EPITHELIAL CELLS WITH PINOCYTOSIS ENHANCED BY A GENERAL VACUOLATION OF THE CYTOPLASM AND PROFOUNDLY ALTERED SPERM MOTILITY AND MORPHOLOGY. |
| Dose amount | 20-30 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |