Experiment 1136520

Worktypes

EFFECTS DUE TO A COMBINATION OF DRUGSPHARMACOLOGY OF COMPOUND - IN HUMANSTOXICITY MARKER CODE

Compounds isolated

LEUROCRISTINE

Alerts

A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.

Details

PropertyValue
Pharmacology
NEUROTOXIC ACTIVITY
Administration routeIV
OrganismEmpty organism
CitationARNOLD,AM: KELLEHER,LH: RENDELL,SG: LEVINE,MN:. (1985). ACUTE VINCRISTINE NEUROTOXICITY.. 1985(8424)
Amount utilized
Compound isolated
DiseaseDOSE LIMITING NEUROTOXICITY IS REPORTED FOR PATIENTS RECEIVING COMBINATION CHEMOTHERAPY IN STAGE II BREST CARCINOMA.PATIENT RECEIVED VINCRISTINE AT A DOSE OF 1.4 MG/SG.M WEEKLY FOR 4 WEEKS AND THEN MONTHLY WITH CYCLOPHOSPHAMIDE,METHOTREXATE AND5-FU. SOME PATIENTS WERE GIVEN VINCRISTINE AT 1 MG/SQ.M FOR 4 WEEKS AND THEN ON ALTERNATE WEEKS WITH CYCLOPHOSPHAMIDE,METHOTREXATE,5-FU,PREDNISONE,DOXORUBICIN AND TAMOXIFEN.PATIENTS EXPERIENCED JAW PAIN & BONE PAIN & ABDOMINAL SYMPTOMS OF NEUROTOXICITY.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE