Experiment 1136522

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationMARAL,R: MATHE,G: DANTCHEV,D: DELGADO,M: MACHOVER,D: TAPIERO,H: RIBAUD,P: MISSET,JL: GASTIABURU,J:. (1983). ACLACINOMYCIN A: PRESENT STATUS OF EXPERIMENTAL AND CLINICAL STUDIES.. 9(5)
Amount utilized
Compound isolated
DiseaseIN THIS PHASE II TRIAL,45 PATIENTS WITH LEUKEMIA WERE TREATED FOR 6-30 DAYS OF 19 PATIENTS WITH AML,THERE WERE 4 COMPLETE AND 3 PARTIAL REMISSIONS.THE 19 PATIENTS WITH ALL,AND THE II WITH LSL HAD 2 COMPLETE AND 2 PARTIAL REMISSIONS EACH. MYELOSUPPRESSION WAS SEVERE IN ALL PATIENTS AND 4 PATIENTS DIED WITH BONE MARROW APLASIA.THERE WAS HEMORRHAGIC DIARRHEA,NAUSEA AND/OR VOMITING,AND STOMATITIS.ABNORMAL ECG AND CONGESTIVE HEART FAILURE WAS SEEN IN 13 AND 4% OF THE CASES,RESPECTIVELY.
Dose amount10.30 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE