Experiment 1138450
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | POSTMUS,PE: MULDER,NH: SLEIJFER,DT: MEINESZ,AF: VRIESENDORP,R: DE VRIES,EGE:. (1984). HIGH-DOSE ETOPOSIDE FOR REFRACTORY MALIGNANCIES: A PHASE I STUDY.. 68(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY,22 PATIENTS WITH PROGRESSIVE DISSEMINATED MALIGNANCIES WERE EVALUATED. DOSES WERE GIVEN IN 1.5 HOURS OVER 3 DAYS WITH SIX EQUAL INFUSIONS AT 12 HOURS INTERVALS. THE STARTING DOSE WAS 1.0 G/SQ.M WITH ESCALATIONS OF 0.5 G/SQ.M. PATIENTS RECEIVED FROM 2-10 COURSES. DOSE LIMITING OROPHARYNGEAL MUCOSITIS OCCURED OTHER TOXICITY WAS PRESENT. OF 17 PATIENTS EVALUABLE FOR RESPONSE, THERE WERE 9 PARTIAL RESPONSES, 4 STABLE DISEASES AND 2 PROGRESSIONS. |
| Dose amount | HIG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |