Experiment 1140974

Worktypes

EFFECTS DUE TO A COMBINATION OF DRUGSANTICANCER AND/OR CYTOTOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

ACIVICIN

Alerts

A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.

Details

PropertyValue
Pharmacology
CYTOTOXIC ACTIVITY
OrganismEmpty organism
CitationFISCHER,PH: PAMUKCU,R: BITTNER,G: WILLSON,JKV:. (1984). ENHANCEMENT OF THE SENSITIVITY OF HUMAN COLON CANCER CELLS TO GROWTH INHIBITION BY ACIVICIN ACHIEVED THROUGH INHIBITION OF NUCLEIC ACID PRECURSOR SALVAGE BY DIPYRIDAMOLE.. 44(8)
Amount utilized
Compound isolated
DiseaseTHE VACO 5 CELL LINE WAS USED EFFICIENT SALVAGING OF GUANOSINE,CYTIDINE AND GUANINE BY THE CELLS COULD BLOCK CYTOTOXICITY. THIS COULD BE REVERSED BY ADDITION OF DIPYRIDAMOLE.
Dose amount3.0 MCG
Number1
Qualitative resultACTIVE
AnimalCELL CULTURE
Per unitML
Dose expressionCONC USED