Experiment 1141188
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | BUDMAN,DR: SCHULMAN,P: MARKS,M: VINCIGUERRA,V: WEISELBERG,L: KREIS,W: DEGNAN,TJ:. (1984). PHASE I TRIAL OF VINZOLIDINE.. 68(7/8) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY 21 PATIENTS WITH CARCINOMA OR LYMPHOMAWERE TREATED ONE DAY EVERY 2 WEEKS. SIGNIFICANT RESPONSES WERE SEEN IN TWO PATIENTS WITH LYMPHOMA AND IN ONE WITH SQUAMOUS CELL CARINOMA OF THE LUNG. RECOMMENDED STARTING DOSES ARE 35 MG/M2 IN GOOD-RISK AND 30 MG/M2 IN POOR RISK PATIENTS. THOSE PATIENTS RECEIVING THE HIGH DOSE (45 MG/M2) EXPERIENCED LIFE THREATENING LEUKOPENIA. TOXICITIES SEEN IN OTHER PATIENTS ARE DIARRHEA, NAUSEA, AND MUCOSITIS PATIENTS AT OTHER DOSES ALSO EXPERIENCED LEUKOPENIA, THROMBOCYTOPENIA AND EOSOMP[JO |
| Dose amount | 25.45 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |