Experiment 1141204

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationKOELLER,JM: TRUMP,DL: WITTE,RS: DAVIS,TE: NELSON,RL: TORMEY,DC: RAMIREZ,G:. (1984). PHASE I TRIAL AND PHARMACOKINETICS OF VINZOLIDINE ON A DAILY X 5 ORAL SCHEDULE.. 1984()
Amount utilized
Compound isolated
DiseaseIN THIS PHASE I TRAIL 20 PATIENT WITH SOLID TUMORS WERE TREATED DAYS 1-5, EVERY 28 DAYS, WITH 60% OF THE DOSE ON DAY 1 AND 10% ON DAYS 2-5. AND TRIPHASIC ELIMINATION PATTERN WITH A TERMINAL HALF LIFE OF 50 HRS. WAS SEEN. VOLUME OF DISTRIBUTION WAS 8 L/KG AND THE CLEARANCE RATE WAS 0.113 L/KG/HR. APPARENT STEADY STATE CONCENTRATION OF 10 NG/ML CAN BE ACHEIVED.
Dose amount30.60 MG
Number2
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE