Experiment 1141959
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | JOSS,RA: BRUNNER,KW: GOLDHIRSCH,A:. (1982). MITOMYCIN, HEXAMETHYLMELAMINE, AND VINDESINE AS SECOND-LINE TREATMENT FOR SMALL CELL CANCER OF THE LUNG.. 66(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS TRIAL 13 PATIENTS WITH RELAPSING SMALL CELL LUNG CARCINOMA WERE TREATED WITH A COMBINATION THERAPY OF MITOMYCIN (10 MG/M2 IV ON DAY 1), HEXAMETHYLAMINE (100 MG/DAY PO DAYS 1-14 AND 21-36 AND VINDESINE (3MG/M2 IV DAYS 1, 8, 21, AND 28). THIS CYCLE WAS REPEATED ON DAY 43. IN ONE PATIENT THERE WAS A PARTIAL REMISSION WITH A DRAMATIC SHRINKAGE OF LIVER METASTASIS LASTING FOR 66 DAYS. SIX PATIENTS HAD DISEASE STABILIZATION FOR A MEDIAN OF 77 DAYS AND THERE WERE SIX DISEASE PROGRESSIONS. TOXICITY CONSISTED OF PARESTHESIAS, MUSCLE WEAKNESS, SLIGHT NAUSEA, VOMITING, ONE CASE OF TRANSIENT SERUM CREATININE INCREASE AND HEMATOLOGICAL TOXICITY WITH A MEDIANA LEUKOCYTE NADIR OF 1900/MM3 AND MEDIAN PLATELET NADIR OF 105000/MM3. |
| Dose amount | 10.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |
| Gender | MALE |