Experiment 1142629

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismEmpty organism
CitationJEHN,U: MEZGER,J:. (1985). TREATMENT OF CHRONIC MYELOID LEUKEMIA BLAST CRISIS WITH VINDESINE AND PREDNISONE.. 69(4)
Amount utilized
Compound isolated
DiseaseIN THIS PHASE II TRIAL, 16 PATIENTS WITH CHRONIC MYELOID LEUKEMIA BLAST CRISIS WERE TREATED WITH VINDESINE (GIVEN WEEKLY ON TWO CONSECUTIVE DAYS)AND PREDNISOLONE(ADMINISTERED THE FIRST WEEK AT 75 MG/DAY,SECOND WEEK AT 50 AND THIRD WEEK AT 25 MG/DAY.) THREE PATIENTS HAD COMPLETE REMISSIONS LASTING FROM 1-5 MONTHS, ELEVEN PATIENTS HAD MINOR RESPONSES AND 2 PATIENTS DID NOT RESPOND. LEUKOPENIA AND THROMBOCYTOPENIA WERE SEVERE. THREE PATIENTS HAD COMPLETE REMISSIONS LASTING FROM 1-5 MONTHS, ELEVEN PATIENTS HAD MINOR RESPONSES AND 2 PATIENTS DID NOT RESPOND. LEUKOPENIA AND THROMBOCYTOPENIA WERE SEVERE.
Dose amount2.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE