Experiment 1142695
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | STEWART,DJ: NUNDY,D: MAROUN,JA: TETREAULT,L: PRIOR,J:. (1985). BIOAVAILABILITY, PHARMACOKINETICS, AND CLINICAL EFFECTS OF AN ORAL PREPARATION OF ETOPOSIDE.. 69(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | BIOAVAILABILITY AND PHARMACOKINETICS OF ORAL ETOPOSIDE WAS STUDIES IN 13 PATIENTS WITH ADVANCED LUNG CANCER. PATIENTS WERE GIVEN AN INITIAL COURSE BY IV 1-HOUR INFUSION AT A DOSE OF 100/MG/SQ.M. DAY FOR 4 DAYS. FOR THE SECOND COURSE OF TREATMENT 3 WEEKS LATER, 3 PATIENTS RECEIVED 150, 175 AND 200 MG/SQ.M./DAY P.O. FOR 4 DAYS. THE TEN ADDITIONAL PATIENTS WERE RANDOMIZED TO RECEIVE THE DRUG ORALLY AT 200 MG/SQ.M./DAY OR BY IV 1-HOUR INFUSION AT 100MG/SQ.M./DAY FOR 4 DAYS. PLASMA LEVEL ANALYSIS USING HPLC SHOWED THAT 52% (RANGE OF 17-72%) OF THE ORALLY ADMINISTERED DOSE WAS ABSORBED, (ABSORPTION OF OVER 40% WAS SEEN IN ONLY ONE PATIENT). THE MEAN PEAK PLASMA LEVEL WAS 9.6 UG/ML ORALLY AND 13.0 UG/ML BY IV ADMINISTRATION. OTHER PARAMETERS BY ORAL OR IV ADMINISTRATION RESPECTIVELY,WERE: MEAN ALPHA HALF LIFE OF 0.96 AND 0.82 HOUR,MEAN BETA HALF LIFE OF 7.2 AND 6.8 HOURS,MEAN C X T VALUES OF 75.9 AND 75.3 MG/L/HR,AND MEAN PLASMA CLEARANCES OF 1.44 AND 1.45 L/HOUR/SQ.M. THE MEAN EXTRAPOLATED VOLUMES OF DISTRIBUTION FOR ORALLY AND IV ADMINISTERED ETOPOSIDE WERE 15.2 AND 16.9 L/SG.M. RESPECTIVELY. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |