Experiment 1142696
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | STEWART,DJ: NUNDY,D: MAROUN,JA: TETREAULT,L: PRIOR,J:. (1985). BIOAVAILABILITY, PHARMACOKINETICS, AND CLINICAL EFFECTS OF AN ORAL PREPARATION OF ETOPOSIDE.. 69(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIRTEEN PATIENTS WITH ADVANCED LUNG CANCER WERE TREATED.DOSING CONSISTED OF ONE HOUR IV INFUSION AT A DOSE OF 100MG/SG.M./DAY FOR 4 DAYS.FOR THE SECOND COURSE OF TREATMENT 3 WEEKS LATER,3 PATIENTS RECEIVED 150,175 AND 200 MG/SG.M./DAY FOR 4 DAYS,PO. THE TEN ADDITIONAL PATIENTS WERE RANDOMIZED TO RECEIVE THE DRUG ORALLY AT 200/MG/DAY OR BY IV 1-HOUR INFUSION AT 100 MG/SG.M./DAY. THERE WERE 2 PARTIAL REMISSION, 1 MIXED RESPONSE AND 4 PATIENTS WITH STABLE DISEASE. GRANULOCYTOPENIA WAS SEEN IN PATIENTS. OTHER TOXICITY WAS NAUSEA AND VOMITING, AND ALOPECIA. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |