Experiment 1142810
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | KENNY,JB: SCARFFE,JH: MALEY,WV:. (1983). PHASE II TRIAL OF VINDESINE IN ADVANCED GASTRIC CANCER.. 67(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE II TRIAL, FIFTEEN PATIENTS WITH ADVANCED OR METASTATIC GASTRIC ADENOCARCINOMA WERE TREATED. AN IV BOLUS INJECTION WAS GIVEN WEEKLY FOR 4 WEEKS AND TWICE WEEKLY FOR 2 WEEKS. AFTER 6 INJECTIONS, PATIENTS WERE REASSESSED. PATIENTS WITH STABLE DISEASE AND NO SIGNIFICANT TOXICITY CONTINUED TO RECIEVE MAINTENANCE VINDESINE EVERY 2 WEEKS. NO OBJECTIVE RESPONSES WERE SEEN. AT THE TIME OF REASSESSMENT THERE WERE 10 DISEASE PROGRESSIONS. FOUR PATIENTS HAD STABLE DISEASE. REVERSIBLE PERIPHERAL NEUROPATHY WAS A DOSE LIMITING TOXICITY WITH 13 OF 15 PATIENTS DEVELOPING PARESTHESIAS. OTHER TOXICITY INCLUDED CONSTIPATION, MILD ALOPECIA, FEVER, MALAISE AND MYALGIA. HEMOTOLOGIC TOXICITY WAS MILD WITH NO THROMBOCYTOPENIA OR THORMBOCYTOSIS, AND ONLY MINOR DROPS IN WBC COUNT AND HEMOGLOBIN LEVELS. |
| Dose amount | 3.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |