Experiment 1143475
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | D'INCALCI,M: ROSSI,C: SESSA,C: URSO,R: ZUCCHETTI,M: FARINA,P: MANGIONI,C:. (1985). PHARMACOKINETICS OF TENIPOSIDE IN PATIENTS WITH OVARIAN CANCER.. 69(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | EIGHT PATIENTS WITH OVARIAN CANCER WERE TREATED WITH THREE DOSES OF TENIPOSIDE. THE FIRST DOSE WAS BY ONE HOUR INFUSION AT 100 MG/SQ.M., THE SECOND DOSE WAS ON DAY 8 AT 150 MG./SQ.M. BY ONE HOUR INFUSION. THE THIRD DOSE WAS ON DAY 22 AT 150 MG/SQ.M. BY 1 DAY INFUSION. DISSAPPREARANCE FROM PLASMA FOLLOWED A BIEXPONENTIAL DECAY PATTERN. THE MEAN TERMINAL HALF LIFE WAS 6.9, 6.1 AND 9.7 HOURS FOR THE FIRST,SECOND AND THIRD DOSE,RESPECTIVELY.PLASMA LEVELS WERE LOWER IN THE ASCITES THAN IN THE PLASMA AFTER THE FIRST HOUR,BUT LEVELS BECAME SIMILAR OR SLIGHTLY HIGHER AFTER 24 HOURS. ELIMINATION OF UNCHANGED TENIPOSIDE IN THE URINE WAS LESS THAN 10% OF THE TOTAL DOSE. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |