Experiment 1143549
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | KREIS,W: BUDMAN,DR: FREEMAN,J: GREIST,A: NELSON,RL: SCHULMAN,P: MARKS,M: KEVILL,L: VINCIGUERRA,V: DEGNAN,T:. (1984). CLINICAL PHARMACOLOGY STUDIES WIRTH ORALLY ADMINIISTERED 3-H-VINZOLIDINE.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | 3 CANCER PATIENTS WERE WITH TRITIATED DOSES OF 1.5, 29.2 AND 36.5 MG/SQ.M. ABSORPTION HALF TIME WAS 1.13 HRS. WITH A PEAK TIME OF 4 HRS. DECAY OF TOTAL TRITIUM IN THE PLASMA WAS BIPHASIC WITH INITIAL HALF LIFE OF 8.4 HRS. AND TERMINAL HALF LIFE OF 170 HRS. AFTER 2 WKS, 4% OF TOTAL RADIOACTIVITY WAS RECOVERED IN THE URINE AND 55% WAS RECOVERED IN THE FECES. ANALYSIS OF THE PLASMA AND URINE OF PATIENT 3 SHOWED A PREDOMINANCE OF UNCHANGED VINZOLIDINE. |
| Dose amount | 1.36 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |