Experiment 1143812

Details

PropertyValue
Pharmacology
Administration routeIV INFUSION
OrganismEmpty organism
CitationTRUMP,DL: HORTVET,L:. (1985). ETOPOSIDE AND VERY HIGH DOSE CISPLATIN: SALVAGE THERAPY FOR PATIENTS WITH ADVANCED GERM CELL NEOPLASMS.. 69(3)
Amount utilized
Compound isolated
DiseaseIN THIS STUDY, 12 PATIENTS WERE TREATED EVERY 28 DAYS WITH A 5 DAY COURSE OF ETOPOSIDE BY ONE HOUR INFUSION, AND HIGH DOSE CISPLATIN. THIS WAS SALVAGE THERAPY FOR PREVIOUSLY TREATED PATIENTS WITH ADVANCED GERM CELL NEOPLASMS. THERE WERE 5 COMPLETE REMISSIONS, 5 PARTIAL REMISSINS, AND 2 DISEASE PROGRESSIONS. IMPORTANT RENAL IMPAIRMENT WAS NOT SEEN. TOXICITY CONSISTED OF MYELOSUPPRESSION AND NEUROTOXICITY (SIX PATIENTS WITH PERIPHERAL NEUROPATHY AND FIVE WITH DIMINISHED HEARING), AND HYPOMAGNESEMIA.
Dose amount100.0 GM
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitSQ M BODY SURFACE
Dose expressionDOSE