Experiment 1145600

Worktypes

EFFECTS DUE TO A COMBINATION OF DRUGSANTICANCER AND/OR CYTOTOXICITY MARKER CODEPHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

NAPHTHOMYCIN

Alerts

A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.

Details

PropertyValue
Pharmacology
CYTOTOXIC ACTIVITY
OrganismStreptomyces species (STREPTOMYCETACEAE)
CitationOKABE,T: YUAN,BD: ISONO,F: SATO,I: FUKAZAWA,H: NISHIMURA,T: TANAKA,N:. (1985). STUDIES ON ANTINEOPLASTIC ACTIVITY OF NAPHTHOMYCIN, A NAPHTHALENIC ANSAMYCIN, AND ITS MODE OF ACTION.. 38(2)
Amount utilized
Compound isolated
DiseaseEFFECT WAS REVERSED BY THE ADDITION OF SULFHYDRYL COMPOUNDS SUCH AS 2-MERCAPTOETHANOL, DITHIOTHREITOL, AND GLUTATHIONE.
Dose amount1.4 MICROMOLS
Number8
Qualitative resultINACTIVE
AnimalCELL CULTURE
Dose expressionCONC USED