Experiment 1147422
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | MANDELLI,F: AMADORI,S: GIONA,F: ANTONIETTA,M: SPIRITI,A: PASTORE,S: MELONI,G: PAOLUCCI,G:. (1982). VINDESINE IN THE TREATMENT OF REFRACTORY HEMATOLOGIC MALIGNANCIES: PHASE II STUDY.. 6(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE II STUDY, 46 PATIENTS WITH LEUKEMIA WERE TREATED. TWO DOSAGE SCHEDULES WERE EMPLOYED, 5 MG/SQ.M WEEKLY X 4, AND 0.5 MG/SQ.M. EVERY 12 H X 10. MAINTENANCE THERAPY INCLUDED MERCAPTOPURINE AND METHOTREXATE OR HYDROXYUREA. VINDESINE WAS GIVEN AS MAINTENANCE AT MONTHLY INTERVALS ON DAY ONE AT 5 MG/SQ.M WITH PREDNISOLONE. THE OVERALL RESPONSE RATE WAS 28.1%. THERE WERE 8 COMPLETE AND 5 PARTIAL RESPONSES. THESE CAN BE BROKEN DOWN AS FOLLOWS: 3/14 PATIENTS WITH ALL (TWO CR AND ONE PR), 2/12 PATIENTS WITH ANLL (ONE CR AND ONE PR), 4/12 PATIENTS WITH BLAST CRISIS (THREE CR AND ONE PR). 4/8 PATIENTS WITH NHL (TWO CR AND TWO PR). MYELOSUPPRESSION WAS SEVERE LEADING TO 10 DEATHS DURING THE INDUCTION PHASE (7 FROM INFECTION AND 3 FROM HEMORRHAGE). NEUROTOXICITY WAS MILD. PHLEBITIS AND MUCOSITIS WERE ALSO SEEN. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |