Experiment 1150158

Details

PropertyValue
Pharmacology
Administration routeINTRARUMINAL
OrganismSenecio jacobaea (ASTERACEAE)
CitationDICKINSON,JO:. (1980). RELEASE OF PYRROLIZIDINE ALKALOIDS INTO MILK.. 23()
Amount utilized
Compound isolated
DiseaseAS PART OF A STUDY ON THE TOXIC EFFECTS OF PYRROLIZIDINE ALKALOIDS ON LACTATING GOATS AND THEIR YOUNG, GOATS WERE GIVEN DOSES OF THIS PLANT EQUIVELANT TO 1% OF THEIR BODY WEIGHT. NO CHANGE IN ANIMAL WEIGHTS WERE SEEN. AFTER THIS STUDY, WHEN THE GOATS WERE REBRED, 3 OF THE 4 TREATED GOATS ABORTED NEAR TERM GIVING BIRTH TO DEAD YOUNG. ONE OF THE GOATS DIED POSTPARTUM. NECROPSY OF THIS GOAT, AND BIOBSY OF THE GOAT WITH SURVIVING YOUNG, REVEALED SEVERE LIVER DAMAGE.
Dose amount1.0%
Number1
Qualitative resultACTIVE
AnimalGOAT(PREGNANT)
Dose expressionCONC USED
ExtractPLANT