Experiment 1150159
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRARUMINAL |
| Organism | Senecio jacobaea (ASTERACEAE) |
| Citation | DICKINSON,JO:. (1980). RELEASE OF PYRROLIZIDINE ALKALOIDS INTO MILK.. 23() |
| Amount utilized | |
| Compound isolated | |
| Disease | LACTATING GOATS WERE GIVEN DOSES OF THIS PLANT EQUIVELANT TO 1% BODY WEIGHT FOR 125 DAYS. THE MILK FROM THESE GOATS WAS GIVEN TO FOUR KIDS AT A DOSE OF APPROX. 150 ML/KG/DAY. PYRROLIZIDINE ALKALOID CONTENT IN THE PLANT WAS 0.16%. ASSAYS OF THE MILK SHOWED CONTENT OF DIFFERENT PYRROLIZIDINE ALKALOIDS FROM 22 TO 53 MCG/100ML. THERE WAS NO APPRECIABLE BODY WEIGHT LOSS IN THE ADULT GOATS, NOR TOXICITY IN THE KIDS. DOES WERE REBRED AFTER THE STUDY, AND 3 OF THE 4 ABORTED NEAR FULL TERM. THESE YOUNG WERE DEAD AT BIRTH. BIOBSY OF THE ADULT GOATS REVEALED LIVER DAMAGE. |
| Dose amount | 1.0% |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | GOAT |
| Dose expression | CONC USED |
| Extract | PLANT |
| Gender | FEMALE |