Experiment 1150212
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | NEIDHART,JA: YOUNG,DC: KRAUT,E: HOWINSTEIN,B: METZ,EN:. (1986). PHASE I TRIAL OF HOMOHARRINGTONINE ADMINISTERED BY PROLONGED CONTINUOUS INFUSION.. 46(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY PATIENTS WERE TREATED BY CONTINUOUS INFUSION FOR 3 TO 30 DAYS. HEMATOLOGICAL TOXICITY WAS DOSE LIMITING, AND IT WAS FOUND THAT THE BEST DOSING SCHEDULE WAS 1 MG/SQ.M. FOR 30 DAYS. OTHER TOXICITY INCLUDED HYPOTENSION, ANOREXIA, AND FATIGUE. PARTIAL REMISSION WAS SEEN IN ONE PATIENT WITH RECTAL ADENOCARCINOMA AND A LARGE PELVIC MASS CONSISTING OF A 50% DECREASE IN THE SIZE OF THE MASS. |
| Dose amount | 1-4 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |