Experiment 1151104

Details

PropertyValue
Pharmacology
Administration routeSMOKING
OrganismNicotiana tabacum (SOLANACEAE)
CitationBOYD,EJS: WILSON,JA: WORMSLEY,KG:. (1983). SMOKING IMPAIRS THERAPEUTIC GASTRIC INHIBITION.. 1983(8316)
Amount utilized
Compound isolated
DiseasePATIENTS WHO SMOKED AND HAD DUODENAL ULCERS WERE TESTED FOR THE EFFECT OF SMOKING ON CIMETIDINE THERAPY. IN MEASUREMENTS OF NOCTURNAL SECRETION, SMOKING REDUCED THE ANTISECRETORY EFFECT OF CIMETIDINE FROM 86% TO 38%. PEPSIN SECRETION WAS INHIBITED 14% DURING SMOKING COMPARED TO 80% BY NON SMOKERS TAKING CIMETIDINE. IN A STUDY WITH HEALTHY ADULTS, SMOKING HAD NO EFFECT ON CIMETIDINE INDUCED INHIBITION OF PENTAGASTRIN STIMULATED GASTRIC ACID SECRETION.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractLEAVES