Experiment 1155270
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | AJANI,JA: DIMERY,I: CHAWIA,SP: PINNAMANENI,K: BENJAMIN,RS: LEGHA,SS: KRAKOFF,IH:. (1986). PHASE II STUDIES OF HOMOHARRINGTONINE IN PATIENTS WITH ADVANCED MALIGNANT MELANOMA, SARCOMA, AND HEAD AND NECK, BREAST, AND COLORECTAL CARCINOMAS.. 70(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | FIVE PHASE II TRIALS WERE CONDUCTED IN 80 PATIENTS WHO HAD ADVANCED SOLID TUMORS, INCLUDING MALIGNANT MELANOMA, SARCOMA, AND HEAD AND NECK, BREAST, AND COLORECTAL CARCINOMA. DOSE SCHEDULE WAS DAILY FOR FIVE DAYS EVERY 21 DAYS. THERE WERE NO COMPLETE OR PARTIAL REMISSIONS. NAUSEA AND VOMITTING, DIARRHEA, AND FEVER AND CHILLS WERE THE MOST COMMON SIDE EFFECTS. OTHER TOXICITY INCLUDE TWO CASES OF HYPOTENSION AND ONE CASE OF VENTRICULAR TACHYCARDIA. MYELOSUPPRESION WAS SEEN. |
| Dose amount | 3-4 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |