Experiment 1155275
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | LOCKER,GY: LANZOTTI,V: KHANDEKAR,JD: SWEET,D: SHAW,J: BITRAN,J: GORDON,L: KRAUSS,S: JOHNSON,C:. (1986). PHASE II TRIAL OF TENIPOSIDE IN PREVIOUSLY TREATED AND UNTREATED PATIENTS WITH ADVANCED COLORECTAL CARCINOMA: AN ILLINOIS CANCER COUNCIL TRIAL.. 70(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE II TRIAL, 72 PATIENTS WITH PREVIOUSLY TREATED OR UNTREATED COLORECTAL CARCINOMA WERE EVALUATED. TENIPOSIDE WAS ADMINISTERED WEEKLY, WITH A 50% REDUCTION FOR HEMOTOXICITY. LEUKOPENIA WAS SEEN IN THE MAJORITY OF PATIENTS, WITH ONE SEPSIS RELATED DEATH. THERE WERE TWO CASES OF HYPOTENSION, AND ONE CASE OF ANAPHYLACTOID REACTION DURING DRUG ADMINISTRATION. GASTROINTESTINAL TOXICITY WAS MILD. THERE WERE NO COMPLETE OR PARTIAL REMISSIONS. THIRTY PATIENTS HAD PERIODS OF DISEASE STABILIZATION LASTING FROM 2 TO 22 MONTHS. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |