| Disease | 152 MEN WERE ENTERED IN A RANDOMIZED CROSS-OVER CONTROLLED STUDY OF GOSSYPOL AS A CONTRACEPTIVE. 75 MEN WERE GIVEN GOSSYPOL AT 20 MG/DAY FOR 75 DAYS, AND A MAINTENANCE DOSE OF 50 MG/WEEK FOR ONE YEAR.
THE CONTROL GROUP WAS GIVEN A SIMILAR SCHEDULE OF PLACEBO.
OF THE 64 EVALUABLE SUBJECTS, 20 (31%) ACHIEVED AZOOSPERMIA, 39 (61%) HAD SPERM COUNTS BELOW 4 MILLION/CC, 2 (3%) HAD COUNTS OF 5-9 MILLION/CC, AND 3 (5%) HAD COUNTS OF OVER 10 MILLION/CC. A 92% EFFICACY WAS ACHIEVED.
THERE WAS NO DECREASE IN THE INCIDENCE OF FATIGUE,DECREASE OF LIBIDO, OR APPETITE, AS WELL AS MEAN VALUE OF SERUM POTASSIUM, HEMOGLOBIN, BODY WEIGHT OR BLOOD PRESSURES DURING THE LOADING PHASE.
DURING THE ONE YEAR MAINTENANCE PHASE, DIFFERENCES WERE SEEN IN THE INCIDENCE OF FATIGUE AS WELL AS A LOWERING OF SERUM POTASSIUM LEVELS. |