Experiment 1158065
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | STEWART,DJ: MAROUN,JA: LEFEBVRE,B: HERINGER,R:. (1986). NEUROTOXICITY AND EFFICACY OF COMBINED VINCA ALKALOIDS IN BREAST CANCER.. 70(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS STUDY, 17 PATIENTS WITH METASTATIC BREAST CANCER WERE TREATED WITH COMBINATION THERAPY OF LEUROCRISTINE, VINCALEUKOBLASTINE, DOXORUBICIN, AND CYCLOPHOSPHAMIDE. OF 13 PATIENTS EVALUABLE FOR RESPONSE, ONE (8%) ACHIEVED COMPLETE REMISSION, EIGHT (62%) ACHIEVED PARTIAL REMISSIONS, AND THREE (23%) HAD STABLE DISEASE. ACUTE, REVERSIBLE NEUROTOXICITY WAS SEEN AND IS APPARENTLY DUE TO SYNERGISTIC EFFECT OF THE 2 VINCA ALKALOIDS. |
| Dose amount | 4.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |