Experiment 1158088
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | DE VRIES,EGE: MULDER,NH: POSTMUS,PE: VRIESENDORP,R: WILLEMSE,PHB: SLEIJFER,DT:. (1986). HIGH-DOSE TENIPOSIDE FOR REFRACTORY MALIGNANCIES: A PHASE I STUDY.. 70(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I STUDY,18 PATIENTS WITH REFRACTORY DISSEMINATED MALIGNANCIES WERE EVALUATED,TENIPOSIDE WAS GIVEN ON 3 CONSECUTIVE DAYS WITH AN INITIAL DOSE PER COURSE OF 0.3 G/SQ.M. WITH ESCALATIONS TO 0.6 TO 1 G/SQ.M. IN THE 13 PATIENTS EVALUABLE FOR RESPONSE, THERE WERE 5 PARTIAL REMISSIONS,1 MINOR RESPONSE AND 4 STABLE DISEASE. ALL 3 PATIENTS IN THE HIGHEST DOSE GROUP DEVELOPED SEVERE SKIN RASH. LEUKOPENIA AND THROMBOCYTOPENIA WERE DOSE DEPENDENT. A DOSE OF 0.6 G/SQ.M. IS RECOMMENDED FOR PHASE II STUDIES. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |