Experiment 1158089
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | KRIS,MG: O'CONNELL,JP: GRALLA,RJ: WERTHEIM,MS: PARENTE,RM: SCHIFF,PB: YOUNG,CW:. (1986). PHASE I TRIAL OF TAXOL GIVEN AS A 3-HOUR INFUSION EVERY 21 DAYS.. 70(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE I CLINICAL TRIAL,17 PATIENTS WITH ADVANCED SOLID TUMORS WERE GIVEN TAXOL BY 3 HOUR INFUSION EVERY 21 DAYS. THE INITIAL DOSE WAS 15 MG/SQ.M. ESCALATING TO 230 MG/SQ.M. OVER 9 STEPS. THERE WERE NO OBJECTIVE RESPONSES. TOXICITY INCLUDED LEUKOPENIA,THROMPOCYTOPENIA,NAUSEA AND VOMITING,ALOPECIA,TRANSIENT RASHES,INCREASES IN TRIGLYCERIDE LEVELS AND HYPERSENSITIVITY REACTION WAS SEEN IN 3 OF 5 PATIENTS GIVEN 190 MG/SQ.M: THE HYPERSENSITIVITY REACTION CONSISTED OF ACUTE DYSPNEA,GENERALIZED ERYTHEMA, AND HYPOTENISION. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |