Experiment 1158643
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | WOLFF,SN: BIRCH,R: SARMA,P: GRECO,FA:. (1986). RANDOMIZED DOSE-RRESPONSE EVALUATION OF ETOPOSIDE IN SMALL CARCINOMA OF THE LUNG: A SOUTHEASTERN CANCER STUDY GROUP TRIAL.. 70(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED STUDY WAS UNDERTAKEN TO EVALUATE THE DOSE RESPONSE RELATIONSHIP IN TREATMENT OF RECURRENT SMALL CELL CARCINOMA OF THE LUNG. THREE DOSES WERE ADMINISTERED, 300, 600 OR 900 MG/SQ.M. THE DRUG WAS ADMINISTERED IN DIVIDED DOSES ON THREE CONSECUTIVE DAYS. AMONG THE 77 PATIENTS EVALUABLE FOR RESPONSE, THERE WERE 4 PARTIAL RESPONSES, 1 IN THE LOW DOSE,2 IN THE MEDIUM DOSE AND 1 IN THE HIGH DOSE GROUP. MYELLOSUPPRESSION WAS SEVERE WITH SIX RELATED DEATHS. ONE DEATH OCCURED IN THE LOW DOSE GROUP, 2 IN THE MEDIUM DOSE GROUP AND 3 IN THE HIGH DOSE GROUP. GASTROINTESTINAL TOXICITY (NAUSEA, VOMITING OR STOMATITIS) WAS ALSO SEEN. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |