Experiment 1159912
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | LUEDKE,DW: LUEDKE,SL: MARTELO,O: QUESENBERRY,P: BIRCH,R: SCHLUETER,J: HAKE,J: LOGAN,T:. (1986). VINDESINE AND MITOMYCIN IN THE TREATMENT OF ADVANCED NON-SMALL CELL LUNG CANCER: A SOUTHEASTERN CANCER STUDY GROUP TRIAL.. 70(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS STUDY, 130 PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER WERE TREATED WITH COMBINATION THERAPY OF VINDESINE (3 MG/SQ.M.) ON DAY 1 AND WEEKLY FOR 6 WEEKS, AND MITOMYCIN C (20 MG/SQ.M.) ON DAY 1. AMONG THE 113 PATIENTS EVALUABLE FOR RESPONSE, THERE WERE 5 COMPLETE, AND 33 PARTIAL REMISSIONS (MEDIAN DURATION 12 WEEKS). TOXICITY CONSISTED PREDOMINANTLY OF BONE MARROW SUPPRESSION AND PERIPHERAL NEUROPATHY. THERE WAS ONE DEATH DUE TO INFECTION RELATED TO NEUTROPENIA. OTHER TOXICITY CONSISTED OF NAUSEA AND VOMITING, ABDOMINAL CRAMPS, STOMATITIS AND DIARRHEA. |
| Dose amount | 3.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |