Experiment 1160101
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ROUTE NOT GIVEN |
| Organism | Empty organism |
| Citation | KNOX-MACAULAY,HHM: MUHANNA,FAM: BUKHARIE,HA:. (1985). ACUTE VINCRISTINE NEUROTOXICITY.. 1985() |
| Amount utilized | |
| Compound isolated | |
| Disease | A 44-YEAR-OLD WOMAN WAS BEING TREATED FOR NON-HODGKIN'S LYMPHOMA WITH A COMBINATION OF CYCLOPHOSPHAMIDE, VINCRISTINE(LYOPHYLIZED), PREDNISOLONE AND BLEOMYCIN. 3 DAYS AFTER HER SECOND VINCRISTINE DOSE OF 2 MG SEVERE CONSTIPATION AND LOWER LIMB BONE PAIN DEVELOPED. THIS WAS FOLLOWED WITHIN 48 HRS BY PARESTHESIAE, NUMBNESS AND LOSS OF ALL SENSORY MODALITIES EXCEPT POSITION SENSE IN BOTH LOWER LIMBS. ALSO, AREFLEXIA AND SEVERE WEAKNESS OF BOTH LOWER LIMBS, INABILITY TO WALK, AND FOOT-DROP. SIX MONTHS LATER, SIGNIFICANT RESIDUAL LOWER LIMB MUSCLE WEAKNESS AND FOOT-DROP REMAIN. |
| Dose amount | 2.0 MG |
| Number | 1 |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | FEMALE |