Experiment 1164989
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | KRAILO,MD: KRIVIT,W: SATHER,H: HAMMOND,D:. (1986). PHASE II STUDY OF VINDESINE IN THE TREATMENT OF PEDIATRIC PATIENTS WITH SOLID TUMORS: A REPORT FROM THE CHILDRENS CANCER STUDY GROUP.. 70(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | 85 PATIENTS WITH RELAPSED SOLID TUMOR WERE TREATED. VINDESINE WAS GIVEN WEEKLY BY BOLUS INJECTION. ONE PATIENT WITH NEUROBLASTROMA ACHIEVED PARTIAL REMISSION. STABLE DISEASE WAS SEEN IN SEVEN PATIENTS, 3 WITH OSTEOGENIC SARCOMA, 2 WITH WILMS' TUMOR, 1 WITH RHABDOMYOSARCOMA AND 1 WITH MEDULLOBLASTOMA. SIGNIFICANT NEUROLOGICAL TOXICITY WAS SEEN IN 20 PATIENTS. SYMPTOMS INCLUDED SEVERE WEAKNESS, SENSORY LOSS, OR DEBILITATING PAIN IN THE EXTREMITIES. 39 PATIENTS HAD SIGNIFICANT HEMOTOLOGIC TOXICITY, CONSISTING PRIMARILY OF ANEMIA AND THROMBOCYTOPENIA. |
| Dose amount | 4.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN CHILD |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |