Experiment 1168045
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | WINTON,EF: MC CUE,PA:. (1986). HIGH INCIDENCE OF VENO-OCCLUSIVE DISEASE RELATED TO INDICINE N-OXIDE IN THE TREATMENT OF REFRACTORY ADULT ACUTE LEUKEMIA.. 70(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | REVIEWS DATA CONCERNING A HIGH INCIDENCE OF HEPATOTOXICITY IN A PHASE II STUDY OF THIS DRUG IN 1982. SIX PATIENTS WITH ACUTE REFRACTORY LEUKEMIA WERE ENTERED IN THIS STUDY. THE DRUG WAS INFUSED OVER 5 MIN DAILY FOR 5 DAYS. HEPATOTOXICITY BECAME EVIDENT BETWEEN DAYS 21 AND 36 OF PROTOCOL. LIVER AUTOPSY OF 5 OF THE 6 PATIENTS REVEALED VENO-OCCLUSIVE DISEASE IN 4 PATIENTS, EDEMA, CONGESTION AND HEPATOCELLULAR NECROSIS LIMITED TO THE CENTRAL VENOUS AREA WERE NOTED. THE FIFTH PATIENTS SHOWED FIBROSIS OF THE CENTRAL VEIN AND INTIMAL PROLIFERATION OF SEVERAL SUBLOBULAR VEINS, BUT NO VENOUS OCCLUSION OR CENTRILOBULAR NECROSIS. |
| Dose amount | 3.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |