Experiment 1169975

Details

PropertyValue
Pharmacology
Administration routeINTRAUTERINE
OrganismEmpty organism
CitationTHOMPSON,MA: LASLEY,BL: RIDEOUT,BA: KASMAN,LH:. (1984). CHARACTERIZATION OF THE ESTROGENIC PROPERTIES OF A NONSTEROIDAL ESTROGEN, EQUOL, EXTRACTED FROM URINE OF PREGNANT MACAQUES.. 31()
Amount utilized
Compound isolated
DiseaseFAILED INCREASED UTERINE WEIGHT IN THE LONG TERM (48 H) UTERINE WEIGHT GAIN ASSAY. HOWEVER, ASSAYS OF UTERINE CYTOSOL REVEALED AN INCREASE IN PROGESTERONE RECEPTORS AND A DEPLETION OF FREE UTERINE CYTOSOL BINDING SITES. IN THE UTERINE NUCLEAR RECEPTOR BINDING ASSAY, AND THE UTERINE CYTOSOL ESTROGEN RECEPTOR EXCHANGE ASSAY, EQUOL DID NOT DEMONSTRATE AN ESTROGENIC EFFECT.
Dose amount0.5.5 MCG
Number3
Qualitative resultACTIVE
AnimalRAT(OVARIECTOMIZED)
Per unitANIMAL
Dose expressionDOSE
GenderFEMALE