Experiment 1170166

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeINTRAGASTRIC
OrganismEmpty organism
CitationLU,GW: ZOU,YJ: MO,QZ: HUANG,J: CHU,DQ: YE,DY:. (1986). CIRCADIAN EFFECT ON GASTRODIN PHARMACOKINETICS IN RATS.. 7(2)
Amount utilized
Compound isolated
DiseaseTHE EFFECT OF CIRCADIAN RHYTHM ON THE PHARMACOKINETICS OF GASTRODIN WAS INVESTIGATED. WHEN GIVEN AT 08:00 HOURS, THE ABSORPTION RATE CONSTANT WAS 1.68, TIME TO REACH PEAK WAS 1.12 H, THE MAXIMUM RADIOACTIVITY IN THE BLOOD WAS 26 CPM/UML, THE AREA UNDER THE CURVE WAS 244 CPM/UML H, AND THE ALPHA AND BETA HALF LIVES WERE 1.3 AND 1.4 H. WHEN GIVEN AT 14:00 HOURS, THE ABSORPTION RATE CONSTANT WAS 2.5, TIME TO REACH PEAK WAS 0.75 H, THE MAXIMUM RADIOACTIVITY IN THE BLOOD WAS 31 CMP/UML, THE AREA UNDER THE CURVE WAS 228 CPM/UML H, THE ALPHA AND BETA HALF LIVES WERE 0.8 AND 16 H.RESP WHEN GIVEN AT 20:00 HOURS, THE AVSORPTION RATE CONSTANT WAS 4 TIME TO REACH PEAK WAS 0.7 H,THE MAXIMUM RADIOACTIVITY IN THE BLOOD WAS 32 CPM/UML,THE AREA UNDER THE CURVE WAS 188 CPM/UML H, AND THE ALPHA AND BETA HALF LIVES WERE 1.2 AND 11 H, RESPTVLY WHEN GIVEN AT 02:00 HOURS,THE ABSORPTION RATE CONSTANT WAS 2.1,TIME TO PEAK WAS 0.75 H,MAXIMUMRADIOACTIVITY IN THE BLOOD WAS 25 CPM/UML,AREA UNDER THE CURVE WAS 143 CPM/UML H,AND THE ALPHA AND BETA HALF LIVES WERE 0.8 AND 15 H,RESPECTIVELY.
Dose amount18.5 MOL
Number1
Qualitative resultACTIVE
AnimalRAT
Per unitKG
Dose expressionDOSE