Experiment 1170185
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Pteridium aquilinum (DENNSTAEDTIACEAE) |
| Citation | HIRONO,I: YAMADA,K: NIWA,H: SHIZURI,Y: OJIKA,M: HOSAKA,S: WAKAMATSU,K: KIGOSHI,H: NIIYAMA,K:. (1984). SEPARATION OF CARCINOGENIC FRACTION OF BRACKEN FERN.. 21(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | RATS WERE GIVEN AN INITIAL DOSE OF 780 MG/KG ON DAY 25 AFTER BIRTH FOLLOWED BY 100 MG/KG WEEKLY FOR 7 WEEKS BEGINNING 17 DAYS AFTER THE INITIAL DOSE. 4 OF THE 12 RATS DIED, 2 AFTER THE FIRST 3 DAYS OF TESTING AND THE OTHERS ON DAYS 40 AND 68. AUTOPSY REVEALED SEVERE HEMORRHAGE IN THE SMALL INTESTINE, BLADDER, AND BONE MARROW. 5 OF THE 8 SURVIVING RATS DEVELOPED MAMMARY CANCER. |
| Dose amount | VAR |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |
| Gender | FEMALE |