Experiment 1170759

Details

PropertyValue
Pharmacology
Administration routeGASTRIC INTUBATION
OrganismEmpty organism
CitationPELLETIER,RM: FRIEND,DS:. (1986). SERTOLI CELL JUNCTIONAL COMPLEXES IN GOSSYPOL-TREATED NEONATAL AND ADULT GUINEA PIGS.. 3(7)
Amount utilized
Compound isolated
DiseaseTWO GROUPS OF 7 ANIMALS EACH WERE TREATED FROM DAY 10 TO DAY 30 OR DAY 40 AFTER BIRTH. TOTAL DOSES GIVEN WERE 1500 AND 2250 MG/KG RESPECTIVELY. EXAMINATION OF THE TESTES REVEALED THAT IMPERMEABLE CONTINUOUS JUNCTIONAL ZONES DID NOT DEVELOP IN ADJACENT SERTOLI CELLS, SO GERM CELL COMPARTIMENTALIZATION OF THE SEMINIFEROUS EPITHELIUM WAS ABSENT. GENERALLY, THE LUMINA OF THE SEMINIFEROUS TUBULES WAS ABSENT AND SPERMATOGENESIS DID NOT PROGRESS PAST THE PACHYTENE SPERMATOCYTE STAGE.
Dose amount75.0 MG
Number1
Qualitative resultACTIVE
AnimalGUINEA PIG
Per unitKG
Dose expressionDOSE
GenderMALE