Experiment 1170760
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Empty organism |
| Citation | PELLETIER,RM: FRIEND,DS:. (1986). SERTOLI CELL JUNCTIONAL COMPLEXES IN GOSSYPOL-TREATED NEONATAL AND ADULT GUINEA PIGS.. 3(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | ADULT GUINEA PIGS WERE DOSED DAILY FOR 5 WEEKS. TOTAL DOSE GIVEN WAS 1.575 G/KG. CONTINUOUS JUNCTIONAL ZONES WERE INTACT AT THE BASE OF THE SEMINIFEROUS EPITHELIUM, HOWEVER HIGHER IN THE EPITHELIUM, DISTENSIONS WERE SEEN IN INTERRUPTED JUNCTIONAL STRANDS. SOME OF THE SERTOLI CELL NUCLEI HAD VACUOLATED SPACES BETWEEN SERTOLI CELLS AND CLUMPS OF HETEROCHROMATIN. DISRUPTION OF SPERMATOGENESIS WAS NOTED IN 10% OF THE SEMINIFEROUS TUBULES EXAMINED. SPERMATAZOA FROM THESE ANIMALS WERE IMMOTILE. |
| Dose amount | 45.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | GUINEA PIG |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |