Experiment 1170793
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | MATSUSHITA,A: TAKESUE,H: IKEDA,M: YAMAMOTO,KI: NISHIMORI,T: TSUCHIYAMA,M: ASANO,M:. (1983). GENERAL PHARMACOLOGY OF VINDESINE SULFATE (3) CHANGES IN MOTOR BEHAVIORS AND MUSCLE SPINDLE ACTIVITIES OF THE CAT FOLLOWING CHRONIC ADMINISTRATION OF VINDESINE AND VINCRISTINE.. 25(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | ANIMALS WERE DOSED WITH 0.03 OR 0.06 MG/KG TWICE WEEKLY FOR 8 WEEKS. NO MOTOR CHANGES WERE OBSERVED. ANIMALS SHOWED ANOREXIA, EPILATION AND DIARRHEA. CONDUCTION VELOCITY OF THE NERVE (GIA AFFERENT FIBER) WAS REDUCED SIGNIFICANTLY. THERE WERE NO SIGNIFICANT CHANGES IN THE MAXIMAL DYNAMIC RESPONSES AND DYNAMIC INDICES OF MUSCLE SPINDLE ACTIVATED BY STRETCHING ANKLE EXTENSOR MUSCLES AT THE RATE OF 2 CM/SEC. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CAT |
| Dose expression | DOSE |