Experiment 1170794
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | MATSUSHITA,A: TAKESUE,H: IKEDA,M: YAMAMOTO,KI: NISHIMORI,T: TSUCHIYAMA,M: ASANO,M:. (1983). GENERAL PHARMACOLOGY OF VINDESINE SULFATE (3) CHANGES IN MOTOR BEHAVIORS AND MUSCLE SPINDLE ACTIVITIES OF THE CAT FOLLOWING CHRONIC ADMINISTRATION OF VINDESINE AND VINCRISTINE.. 25(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | ANIMALS WERE DOSED TWICE WEEKLY FOR 8 WEEKS. 2/5 ANIMALS TREATED SHOWED DECREASED MUSCLE TONE AND LIGHT ATAXIA. ANOREXIA, EPILATION AND DIARRHEA WERE ALSO SEEN. CONDUCTION VELOCITY OF THE NERVE (GIA AFFERENT FIBER) WAS REDUCED SIGNIFICANTLY. THERE WERE NO SIGNIFICANT CHANGES IN THE MAXIMAL DYNAMIC RESPONSE AND DYNAMIC INDICES OF MUSCLE SPINDLE ACTIVATE BY STRECTING ANKLE EXTENSOR MUSCLES AT THE RATE OF 2 CM/S EC. |
| Dose amount | 0.03 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CAT |
| Per unit | KG |
| Dose expression | DOSE |