Experiment 1170909
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | BY CHEEK POUCH |
| Organism | Capsicum frutescens (SOLANACEAE) |
| Citation | AGRAWAL,RC: SARODE,AV: LALITHA,VS: BHIDE,SV:. (1985). CHILLI EXTRACT TREATMENT AND INDUCTION OF EYE LESIONS IN HAMSTERS.. 28(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | HAMSTERS WERE DOSED 5X PER WK FROM 8-10 WKS OF AGE UNTIL DEATH. DOSE WAS EQUV. TO 0.5 UG/KG OF CAPSAICIN. EYES OF ANIMALS BECAME SMALLER WITH PALPABRAL FISSURES AND SHRUNKEN EYEBALLS. CHANGES SEEN INCLUDE FOCAL INCREASE IN CORNEAL EPITHELIAL CELLS,HYALINISATION AND THICKENING OF THE SUBSTANTIA PROPRIA OF THE EYEBALL,DISORGANIZATION OF THE RETINAL STRUCTRUE WITH LOSS OF NEURONS,GLASINSINGUA, AND IRIS AND CILLIARY BODIES ADHERENT TO LENS CAPSULE. VITAMIN A LEVELS WERE DECREASED IN THE LIVER. LOWERED SERUM LEVELS WERE ONLY SEEN IN ANIMALS ALSO GIVEN A SINGLE DOSE OF THE CARCINOGEN METYLACETOXYYMETHYL NITROSAMINE. |
| Dose amount | 20.0 MICROLITERS |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HAMSTER |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |