Experiment 1171806
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | WILLSON,JKV: KNUIMAN,MW: SKEEL,RT: WOLTER,JM: PANDYA,KJ: FALKSON,G: CHANG,YC:. (1986). PHASE II CLINICAL TRIAL OF ACIVICIN IN ADVANCED BREAST CANCER: AN EASTERN COOPERATIVE ONOCOLOGY GROUP STUDY.. 70(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE II CLINICAL TRIAL,37 PATIENTS WERE EVALUATED FOR THE THERAPEUTIC EFFECTS OF ACIVICIN IN ADVANCED BREAST CANCER. TREATMENT CONSISTED OF 60 MG/SQ.M. INFUSED OVER 72 HOURS BY CONSTANT IV INFUSION EVERY 21 DAYS. IN PATIENTS WHO DID NOT EXPERIENCE TOXICITY DURING THE FIRST TREATMENT,THE DOSE WAS ESCALATED TO 75 MG/SQ.M.OF THE 25 PATIENTS EVALUABLE FOR RESPONSE,THERE WAS ONE PARTIAL RESPONSE,AND 24 DISEASE PROGRESSIONS.MEDIAN SURVIVAL WAS 17 WEEKS FROM ENTRY. TOXIC EFFECTS INCLUDED NAUSEA AND VOMITING, DIARRHEA, LUEKOPENIA, THROMBOCYTOPENIA, ANEMIA AND NEUROLOGIC TOXICITY. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |