Experiment 1171808
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | BOOTH,BW: KORZU,AH: WEISS,RB: ELLISON,RR: BUDMAN,D: KHOJASTEH,A: WOOD,W:. (1986). PHASE II TRIAL OF ACIVICIN IN ADVANCED BREAST CARCINOMA: A CANCER AND LEUKEMIA GROUP B STUDY.. 70(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE II CLINICAL TRIAL,THE THERAPEUTIC EFFICACY OF ACIVICIN FOR THE TREATMENT OF ADVANCED BREAST CANCER IS EVALUATED. 21 PATIENTS WERE IN THIS TRIAL. GOOD RISK PATIENTS RECEIVED 15 MQ/SQ.M.DAILY FOR 5 DAYS REPEATED EVERY 21 DAYS. POOR RISK PATIENTS WERE GIVEN 12 MG/SQ.M.AT THE SAME DOSING SCHEDULE. THE ONLY RESPONSES SEEN WERE 3 CASES OF TEMPORARILY STABLE DISEASE. TOXICITY WAS SEVERE,WITH 1 CASE OF LIFE THREATENING THROMBOCYTOPENIA,AND ONE DEATH RELATED TO NEUTROPENIA. NAUSEA, VOMITING AND MILD TO MODERATE NOUROTOXICITY WERE SEEN. NEUROTOXIC SYMPTOMS INCLUDED LETHARGY, CONFUSION AND DEPRESSION. |
| Dose amount | 12.15 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |