Experiment 1171982
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | MUSS,H: BINDY,BN: DISAIA,PJ: TWIGGS,LB:. (1986). TENIPOSIDE IN EPITHELIAL OVARIAN CARCINOMA: A PHASE II TRIAL OF THE GYNECOLOGIC ONCOLOGY GROUP.. 70(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | IN THIS PHASE II CLINICAL TRIAL, THE THERAPEUTIC EFFICACY OF TENIPOSIDE IN GYNECOLOGIC MALIGNANCY WAS EVALUATED. THE DRUG WAS GIVEN BY 30 TO 60 MIN INFUSION OF 100 MQ/SQ.M/ WEEK TO A MAXIMUM DOSE OF 160 MG/SQ.M OF 26 PATIENTS EVALUABLE FOR RESPONSE, THERE WERE 3 PARTIAL RESPONSES IN PALPABLE LESIONS WHICH LASTED FOR 3.6 TO 5.9 MONTHS. TOXICITY WAS MODERATE. 3 PATIENTS DEVELOPED SERVERE NEUTROPENIA, FEVER AND PRESUMED SEPSIS. MILD NAUSEA AND VOMITING WERE SEEN IN 6 PATIENTS. |
| Dose amount | 100.0 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | SQ M BODY SURFACE |
| Dose expression | DOSE |