Experiment 1173264
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | GASTRIC INTUBATION |
| Organism | Cycas circinalis (CYCADACEAE) |
| Citation | SPENCER,PS: NUNN,PB: HUGON,J: LUDOLPH,A: ROY,DN:. (1986). MOTORNEURONE DISEASE ON GUAM: POSSIBLE ROLE OF A FOOD NEUROTOXIN.. 1986(8487) |
| Amount utilized | |
| Compound isolated | |
| Disease | PRODUCES A DEGENERATIVE MOTOR SYSTEM DISEASE WITHIN 8 WEEKS OF INTOXICATION. THIS IS CHARACTERIZED BY PYRAMIDAL DYSFUNCTION, LIMB WEAKNESS, ATROPHY, UPPER-EXTREMETY TREMOR, WRIST DROP, BRADYKINESIA, BEHAVIORAL CHANGES, AND CONDUCTION DEFICITS OF PERIPHERAL MOTOR PATHWAYS. DEGENERATION WAS SEEN IN THE GIANT BETZ CELLS OF THE MORTOR CORTEX AND LOWER MOTOR NEURONS. |
| Dose amount | 0.81 MILLIMOLS |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | MONKEY(CYNOMOLGUS) |
| Per unit | KG |
| Dose expression | DOSE |